Biomarker discovery and validation: the tide is turning

Biomarker discovery and validation.

Currently available biomarkers, such as those used to diagnose myocardial infarction (e.g., cardiac troponins), were identified in the course of targeted physiologic studies. Similarly, basic investigation of diseases has largely been characterized by studies of isolated molecules in cellular systems. Advances in genomics technologies, however, are beginning to permit characterization of global...

Turning the tide against tuberculosis.

HIV and maternal mortality: turning the tide.

The two top causes of death in women of reproductive age globally are HIV/AIDS and complications related to pregnancy and childbearing, which account for 19% and 15% of all deaths in women aged 15–44 years, respectively. The growing burden of HIV infection in young sexually active women and the maternal health problems that they face have been described as two intersecting epidemics. In setting...

Neuroimaging-based biomarker discovery and validation.

Although developing biological markers for chronic pain has been a major goal of the field for decades, such biomarkers have not yet made their way into clinical practice. However, given the potential uses of biomarkers in multiple aspects of prevention and treatment—suchaspain and risk factor assessment, diagnosis, prognosis, treatment selection, drug discovery, and more—efforts to discover ne...

Screening mammography: the turning of the tide?

that many of the legion of criticisms that have been placed at the door of the nbss simply do not hold up to scrutiny. But mud sticks, and so many observers who do not like the results of the nbss point again and again to the same " flaws. " One of Narod's most telling points is that the survival curves for the two arms of the Swedish trial continue to remain separate up to 29 years after the t...